KMID : 0360220210620050612
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Journal of the Korean Ophthalmological Society 2021 Volume.62 No. 5 p.612 ~ p.620
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Efficacy of 0.15% Sodium Hyaluronate Eye Drops in Patients¡¯ Ocular Surface after Upper Eyelid Surgery
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Nam Jeoung-Woo
Park Do-Hee Yoon Hyeon-Jeong Yoon Kyung-Chul
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Abstract
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Purpose: To evaluate the clinical efficacy of preservative-free 0.15% sodium hyaluronate eye drops on the ocular surface after upper eyelid surgery.
Methods: This study included 43 patients who underwent upper eyelid surgery between December 2018 and May 2019. Patients were randomly assigned to group A (those treated with preservative-free 0.15% sodium hyaluronate eye drops) and group B (the control group). Ocular surface disease index score (OSDI), tear break up time (TBUT), Schirmer¡¯s test, corneal staining score (CSS), meibomian gland (MG) quality, MG expressibility, and meiboscore were evaluated before surgery and at 1 week, 1 month, and 2 months after surgery.
Results: In group A, OSDI and TBUT showed a significant increase at 1 week after surgery compared with baseline values (all p < 0.05). In group B, OSDI, TBUT, and CSS were significantly higher at 1 week and 1 month after surgery (all p < 0.05), whereas there were no significant changes at 2 months after surgery compared with baseline values. At 1 month after surgery, OSDI (p = 0.03) and CSS (p < 0.01) showed significant changes between group A and group B; however, there was no significant change in the TBUT. There were no significant within-group differences in Schirmer¡¯s test values, MG quality, MG expressibility, or meiboscore, and there were no significant between-group differences over time.
Conclusions: Preservative-free 0.15% sodium hyaluronate eye drops were shown to be an effective treatment for early dry-eye symptoms and ocular surface damage after upper eyelid surgery.
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KEYWORD
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Dry eye, Sodium hyaluronate eye drops, Upper eyelid surgery
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